ZM241385_COA_20300_MedChemExpress

细胞自噬染色检测试剂盒(MDC 法)产品简介：碧云天生产的细胞自噬染色检测试剂盒(MDC 法)，即Autophagy Staining Assay Kit with MDC ，是一种使用丹酰尸胺，也称单丹磺酰尸胺、丹酰尸胺或丹酰戊二胺(monodansylcadaverine, MDC)作为荧光探针快速便捷地检测细胞自噬的试剂盒。

自噬(autophagy)是一种在进化上高度保守的通过溶酶体吞噬并降解部分自身组分的细胞内分解代谢途径。

自噬与多种生理功能有关，在饥饿等环境条件下，细胞通过自噬降解多余或异常的细胞内组分，为细胞的生存提供能量及原材料，促进生物体的生长发育、细胞分化及对环境变化产生应答。

自噬异常与多种病理过程如肿瘤、神经退行性疾病、代谢疾病、病原体感染等都有密切关系。

由于细胞自噬在生理和病理过程中都有重要作用，自噬已经成为细胞生物学领域的一个研究热点。

MDC 是细胞自噬检测最常用的荧光探针之一。

MDC 可以通过离子捕获(ion trapping)和与膜脂的特异性结合，从而特异性标记自噬体(autophagosome)，也称autophagic vacuole ，因而常用于细胞自噬的检测。

MDC 是一种嗜酸性荧光探针，很多酸性膜性结构也会被MDC 染色，因此MDC 染色时正常的细胞也会有一定的染色背景。

本产品的染色原理决定了本产品只能用于培养的细胞或者组织的细胞自噬荧光染色检测，不能用于冻存的或固定的细胞、组织或者组织切片的染色检测。

使用本产品染色后可以通过荧光显微镜拍照观察，也可以通过荧光酶标仪或流式细胞仪进行荧光检测。

荧光显微镜观察时可以使用紫外区激发光激发，发出绿色荧光。

荧光酶标仪或流式细胞仪推荐的激发波长为335nm (330-360nm 均可)，发射波长为512nm (510-540nm 均可)。

本产品用于细胞自噬染色的效果参考图1。

图1. 细胞自噬染色检测试剂盒(MDC 法)的染色效果图。

Inhibitors, Agonists, Screening Libraries Data SheetBIOLOGICAL ACTIVITY:ZM 241385 is a novel non–xanthine adenosine receptor antagonist with selectivity for the A2a receptor subtype.Target: adenosine receptorin vitro: ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'–N–ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52. [1]in vivo: ZM 241385 has low potency at A2b receptors and antagonized the relaxant effects of adenosine in the guinea–pig aorta. ZM 241385 has a low affinity at A1 receptors. In rat cerebral cortex membranes it displaces tritiated R–phenylisopropyladenosine (R–PIA)with a pIC50 of 5.69. [2]PROTOCOL (Extracted from published papers and Only for reference)Enzyme assay [1]The activity of ZM 241385 was determined against a range of phosphodiesterase enzymes from rat hepatocytes and comparedwith the activity of theophylline. Isolated hepatocytes were prepared from fed male Sprague Dawley rats and incubated. Cells (3–5 mg dry weight/ml) were pre–incubated at 37°C for 20 min, with constant gassing (95% 02/5% CO2), before use. Cyclic AMPphosphodiesterase activity was measured by a modification of the two step procedure. All assays were performed at 30°C in the presence of cyclic AMP (1 μM).Animal administration [1]Dunkin Hartley guinea–pigs (male 250–400 g) were killed by cervical dislocation and their atria removed and immersed in Krebs solution. The atrial pairs were mounted in organ baths containing oxygenated Krebs solution (95% 02/5% C02) at 37°C . Thenucleoside transport inhibitor, dipyridamole (10 gM) was present in the Krebs solution since the agonist, 2–chloroadenosine (2–CADO)has been shown to be a substrate for the transporter. Adenosine deaminase (2 u/ml) was added to remove endogenous tissue adenosine. The spontaneously beating atria were placed under a resting tension of 1 g and allowed to equilibrate for 50 min with continuous overflow. 2–CADO (range 0.01μM–10μM) was administered to produce a slowing of atrial rate before and after incubation of test compound for 30 min (ZM 241385, 3μM–30μM). The affinity of ZM 241385 (10μM) for atrial muscarinic receptors was determined using carbachol (0.01μM–3μM) concentration–response curves.References:[1]. Poucher SM, et al. The in vitro pharmacology of ZM 241385, a potent, non–xanthine A2a selective adenosine receptor antagonist. Br J Pharmacol. 1995Jul;115(6):1096–102.Product Name:ZM241385Cat. No.:HY-19532CAS No.:139180-30-6Molecular Formula:C 16H 15N 7O 2Molecular Weight:337.34Target:Adenosine Receptor Pathway:GPCR/G Protein Solubility:DMSO: ≥ 30 mg/mLCaution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。

美国Medchemexpress化合物库（小分子库）-原装进口，现货供
应，提供组合定制服务
品牌：Medchemexpress （MCE）
保存条件：-20℃
供应商：MCE中国
数量：大量
保质期：2年
Size：
Pre-dissolved DMSO/Solid（Or dry solid）
100 uL/well (10 mM solution)
200 uL/well (10 mM solution)
MedChemExpress (MCE)专注于各种抑制剂、调节剂、API、天然产物及化合物库，总部位于美国新泽西。

MCE经过十年努力已成为全球生物活性小分子领域的一流供应商。

MedChemExpress(MCE)产品涵盖近20个热门研究领域，1000多个细分靶点，超过3000个现货抑制剂、拮抗剂和激动剂。

相关的应用成果已发表于Nature、Cell等国际知名杂志，在全球20余个国家地区设有代理机构。

上海皓元生物医药科技有限公司(MCE 中国) 是MedChemExpress (MCE) 亚洲总代理。

MCE化合物库涵盖20余种不同的类型，超过2500个化合物，进口原装，
现货供应，提供详实的生物活性信息、化学结构信息、质控图谱（NMR和HPLC 等）。

还可根据您的实际研究需要，为您度身定制任意组合、规格、布板的特殊化合物库。

/screening-libraries.html
现有特色化合物库有：。

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MOVEMENT DISORDERS医学35010883-7694MRS BULL MRS BULLETIN工程技术26690301-9268PRECAMBRIAN RES PRECAMBRIAN RESEARCH地学71071615-4150ADV SYNTH CATAL ADVANCED SYNTHESIS & CATALYSIS化学42180957-9672CURR OPIN LIPIDOL CURRENT OPINION IN LIPIDOLOGY医学81131941-7705CIRC-CARDIOVASC QUAL Circulation: Cardiovascular Quality and Ou CARDIAC & CARDI1320003-2700ANAL CHEM ANALYTICAL CHEMISTRY化学26970304-3835CANCER LETT CANCER LETTERS医学84312158-3188TRANSL PSYCHIAT Translational Psychiatry PSYCHIATRY43740969-2126STRUCTURE STRUCTURE生物78331863-2653BRAIN STRUCT FUNCT Brain Structure & Function医学27410306-2619APPL ENERG APPLIED ENERGY工程技术450001-690X ACTA PSYCHIAT SCAND ACTA PSYCHIATRICA SCANDINAVICA医学17750143-5221CLIN SCI CLINICAL SCIENCE医学57371355-6037HEART HEART医学82852045-2322SCI REP-UK Scientific reports Natural Science Disciplines 47861052-9276REV MED VIROL REVIEWS IN MEDICAL VIROLOGY医学34040749-6419INT J PLASTICITY INTERNATIONAL JOURNAL OF PLASTIC工程技术24600268-960X BLOOD REV BLOOD REVIEWS医学64761522-8517NEURO-ONCOLOGY NEURO-ONCOLOGY医学18600160-4120ENVIRON INT ENVIRONMENT INTERNATIONAL环境科学24800269-9370AIDS AIDS医学2780007-1323BRIT J SURG BRITISH JOURNAL OF SURGERY医学13480043-1354WATER RES WATER RESEARCH环境科学57241354-3784EXPERT OPIN INV DRUG EXPERT OPINION ON INVESTIGATIONA医学7550022-0957J EXP BOT JOURNAL OF EXPERIMENTAL BOTANY生物7450022-0477J ECOL JOURNAL OF ECOLOGY环境科学77031759-9954POLYM CHEM-UK POLYMER CHEMISTRY POLYMER SCIENCE 82141994-0416CRYOSPHERE Cryosphere GEOGRAPHY, PHY 18630160-6689J CLIN PSYCHIAT JOURNAL OF CLINICAL PSYCHIATRY医学67821549-9618J CHEM THEORY COMPUT J ournal of Chemical Theory and Computat化学65401527-8999CHEM REC CHEMICAL RECORD化学61951465-542X BREAST CANCER RES BREAST CANCER RESEARCH ONCOLOGY。

[29] Quciroz DM, Rocha GA, Rocha AM, ct al. dupA polymorphismsand risk of Heh’coiacter _py!ori-asso(:iate(l diseases [J]. Int J Med Microbiol, 2011, 301(3): 225-228.[30] Hussein NR, Abdullah SM, Salih AM, ct al. dupA1 is associatedwith duodenal ulcer and high interleukin-8 secretion from the gastric mucosa [J]. Infect Immun, 2012, 80(8): 2971-2972.[31] Moura SB, Costa RF, Anacleto C, et al. Single nucleotidepolymorphisms of Heh’coBacter pyJori dupA that lead to premature stop codons [J]. Helicobacter, 2012, 17(3): 176-180. [32] Kim JY, Kim N, Nam RH, et al. Association of polymorphisms invirulence factor of HeJicoLacter pjJori and gastroduodenal diseases in South Korea [J]. J Gastroenterol Hepatol, 2014, 29(5): 984-991.[33] Fatahi G, Talebi Bezmin Abadi A, Peerayeh SN, et al. Carrying a112bp-segment in ffeiicoLacter priori dupA may associate with increased risk of duodenal ulcer [J]. Infect Genet Evol, 2019, 73: 21-25.[34] Robinson K, Argent RHAtherton JC. The inflammatory andimmune response to ffdicohacter priori infection [J]. Best Pract Res Clin Gastroenterol, 2007, 21(2): 237-259.[35] Kuipers EJ, Uyterlinde AM, Pena AS, et al. Increase ofHelicobacter pylori-associated corpus gastritis during acid suppressive therapy: implications for long-term safety [J]. Am JGastroenterol, 1995, 90(9): 1401-1406.[36] Atherton JC. The pathogenesis of 丑ehcohacter _pjiori-inducedgastro-duodenal diseases [J]. Annu Rev Pathol, 2006, 1: 63-96. [37]马涛，郭文婷，宋丹利，等.不同年龄组急性缺血性脑卒中患者机械取栓治疗有效性和安全性的Meta分析[J].中国循证医学杂 志，2020,20(4):412-417.[38] Crabtree JE, Wyatt JI, Trejdosiewicz LK, et al. Interleukin-8expression in 只ehco办actor pyJori infected, normal, and neoplastic gastroduodenal mucosa [J]. J Clin Pathol, 1994, 47(1): 61-66. [39] Yin YW, Hu AM, Sun QQ, et al. Association betweeninterleukin-8 gene -251 T/A polymorphism and the risk of peptic ulcer disease: a meta-analysis [J]. Hum Immunol, 2013, 74(1): 125-130.[40] Ando T, Kusugami K, Ohsuga M, et al. Interleukin-8 activitycorrelates with histological severity in Helicobacter pylori-associated antral gastritis [J]. Am J Gastroenterol, 1996, 91(6): 1150-1156.(收稿日期：2021-02-07)左旋紫草素骨靶向自组装纳米粒的制备及质量表征郑德志，王婷婷，刘瑞杰，张健，李城明，邓凯文，肖雯婧，侯君[摘要1目的制备左旋紫草素骨靶向自组装纳米粒。

北京春达科技有限公司专营进⼝体外诊断试剂⼯业原料，透析产品，纯化填料，标准品SCLPP209碱性磷酸酶3.1.3.1Alkaline phosphatase from Calf intestine-Activity: >30000 U/mlGlycerol solution-Mw: 100,000-Store at -20 °CSCMAD211苹果酸脱氢酶1.1.1.37Malate dehydrogenase from Microorganism-Activity: >40 U/mgYellowish amorphous powder-Mw: 140,000-Store at -20 °CSCMDH18C苹果酸脱氢酶1.1.1.37Malate dehydrogenase from Pig heart-Activity: >1250 U/mgprot.White amorphous powder-Mw:140,000-Store at -20 °CSCMDL100苹果酸脱氢酶1.1.1.37Malate dehydrogenase from Microorganism-Activity: >60 U/mgWhite amorphous powder-Mw: 80,000-Store at -20 °CSCMUT11C变旋酶5.1.3.3Mutarotase from Porcine kidney-Activity: >1500 U/mgWhite amorphous powder-Mw: 40,000-Store at -20 °CSCMUT12C变旋酶5.1.3.3Mutarotase from Porcine kidney-Activity: >1000 U/mlAmmonium sulfate suspension-Mw: 40,000-Store at 2-8 °CSCNAL301唾液酸醛缩酶4.1.3.3N-Acetylneuraminic acid aldolase from MicroorganismActivity: >15 U/mg-Yellowish amorphous powderMw: 98,000-Store at -20 °CSCPCO301原⼉茶酸3,4双加氧酶1.13.11.3Protocatechuate 3,4-dioxygenase from Pseudomonas sp.Activity: >3 U/mg-Light brown amorphous powderMw: 700,000-Store at -20 °CSCPEO131过氧化物酶1.11.1.7Peroxidase from Horseradish, Grade IActivity: >250 U/mg-Reddish-brown amorphous powderMw: 40,000-Store at -20 °CSCPEO301过氧化物酶1.11.1.7Peroxidase from Horseradish, Grade I-Activity: >250 U/mgReddish-brown amorphous powder-Mw: 40,000-Store at -20°CSCPEO302过氧化物酶1.11.1.7Peroxidase from Horseradish, Grade III-Activity: >110 U/mgReddish-brown amorphous powder-Mw: 40,000-Store at -20°CSCPHO12C磷脂酶D Phospholipase D from Streptomyces chromofuscus3.1.4.4Activity: >40 U/mg-Brown amorphous powderMw: 57,000-Store at -20 °CSCPNP301嘌呤核苷磷酸化酶2.4.2.1Purine-nucleoside phosphorylase from MicroorganismActivity: >15 U/mg-White amorphous powderMw: 120,000-Store at -20 °CSCPPC301磷酸烯醇式丙酮酸羧化酶4.1.1.31Phosphoenolpyruvate carboxylase from Corn leavesActivity: >5 U/mg-White amorphous powderMw: 390,000-Store at -20 °CSCPSP101脯氨酸特定的肽链内切酶3.4.21.26Proline specific endopeptidase from Flavobacterium sp.Activity: >5 U/mg-White amorphous powder-Mw: 78,000-Store at -20 °CSCPYK302L丙酮酸激酶2.7.1.40Pyruvate kinase from Rabbit muscle-Activity:＞2000 U/mlwhite ammonium sulphate suspension-Mw:237000-Store at 2-8℃SCPYO311丙酮酸氧化酶1.2.3.3Pyruvate oxidase from Microorganism-Activity: >1.5 U/mgYellowish amorphous powder-Mw: 260,000-Store at -20 °CSCSAO341肌氨酸氧化酶1.5.3.1Sarcosine oxidase from Microorganism-Activity: >8 U/mgYellowish amorphous powder-Mw: 65,000-Store at -20 °CSCSAO351肌氨酸氧化酶1.5.3.1Sarcosine oxidase from Microorganism-Activity: >8 U/mgYellowish amorphous powder-Mw: 43,000-Store at -20 °CSCSOD302超氧化物歧化酶1.15.1.1Superoxide dismutase from Bovine erythrocyte-Activity: >3000U/mgBluish-green amorphous powder-Mw: 32,000-Store at -20 °CSCUAO201尿酸酶1.7.3.3Uricase from Candida sp.-Activity: >4 U/mg-White amorphous powder-Mw: 120,000-Store at -20 °CSCUAO211尿酸酶1.7.3.3Uricase from Bacillus sp.-Activity:>1.5 U/mg-White amorphous powder-Mw: 150,000-Store at -20 °CSCURH10S脲酶3.5.1.5Urease from Jack bean-Activity: >220 U/mg-White amorphous powder-Mw: 480,000-Store at -20 °CSCURH16C脲素酶GUrease G from Jack bean-Activity: >150 U/mgWhite amorphous powder-Mw: 480,000-Store at -20 °C3.5.1.5SCURH201脲素酶Urease from Jack bean-Activity: >100 U/mgWhite amorphous powder-Mw: 480,000-Store at -20 °C3.5.1.5SCXTO212黄嘌呤氧化酶Xanthine oxidase from Microorganism-Activity: >10 U/mgReddish-brown amorphous powder-Mw: 160,000-Store at -20°C1.1.3.222.诊断与研究⽤的辅酶CODES PRODUCTS CAS #SCADP01C 腺苷5'-⼆磷酸单钾盐⼆⽔合物ADP-K.2H2O-Adenosine 5’-diphosphate monopotasium saltdihydrate-C10H14N5O10P2K.2H2O-Mw:501.30-Colorless crystals-Purity:>95 %72696-48-1SCADP22C 腺苷5’-⼆磷酸⼆钠盐ADP-Na2-Adenosine 5’-diphosphate disodium salt-C10H13N5O10P2Na2-Mw:471.20-White powder-Purity:>98 %16178-48-6SCAMP02C 腺苷-5’-磷酸AMP-Adenosine 5’-monophosphoric acid-C10H14N5O7P.H2O-Mw:365.20-White powder-Purity:>98 %18422-05-4SCAMP05C 腺苷5’-磷酸AMP-Na2-Adenosine 5’-monophosphate disodium salt -C10H12N5O7PNa2-Mw:391.18-White powder-Purity:>95%18422-05-4SCATP03C 腺苷5’-三磷酸⼆钠盐3⽔合物ATP-Na2.3H2O-Adenosine 5’-triphosphate disodium salttrihydrate -C10H14N5Na2O13P3.3H2O -Mw:605.19-White powder-Purity:>96 %987-65-5SCBNA207C β-烟酰胺-腺嘌呤⼆核苷酸NAD-β-Nicotinamide-adenine dinucleotide-C21H27N7O14P2-Mw:663.4-White powder-Purity:>98 %53-84-9SCBND210C β-烟酰胺腺嘌呤⼆核苷磷酸，还原型四钠盐NADPH-Na4-β-Nicotinamide-adenine dinucleotide phosphate, reducedtetrasodium salt-C21H26N7O17P3.Na4-Mw:833.40-White powder-Purity:>93 %2646-71-1SCBNH208C β-烟酰胺腺嘌呤⼆核苷酸，还原⼆钠盐NADH-Na2-β-Nicotinamide-adenine dinucleotide, reduceddisodium salt -C21H27N7P2O14Na2-Mw:709.40-White to yellowish powder-Purity:>93 %606-68-8β-烟酰胺腺嘌呤⼆核苷酸磷酸⼆钠盐24292-60-2SCBNP209C β-烟酰胺腺嘌呤⼆核苷酸磷酸⼆钠盐NADP-Na2-β-Nicotinamide-adenine dinucleotide phosphatedisodium salt-C21H26N7O17P3Na2-Mw:787.40-Yellowishpowder-Purity:>97 %24292-60-2SCCOA11C 辅酶A三锂盐Coenzyme A trilithium salt-C21H33Li3N16O7P3S-Mw:785.40-White powder-Purity:>85 %18439-24-2SCDAD631C ⼆(腺苷-5’-)五磷酸三锂盐Ap5A-Li3-P1,P5 –Di(adenosine -5’-)pentaphosphate trilithiumsalt-C20H26N10O22P5Li3-Mw:934.20-Yellowish powder-Purity:>95 %75522-97-3SCFAD11C 黄素腺嘌呤⼆核苷酸⼆钠盐FAD- Na2-Flavine-adenine dinucleotide disodium salt-C27H31N9O15P2Na2-Mw:829.60-Orange powder-Purity:>93 %146-14-5SCNAL24C N-⼄酰-L-半胱氨酸N-Acetyl-L-cysteine-C5H9NO3S-Mw:163.20-White powder-Purity:>98 %616-91-1SASNAD 硫代辅酶IThio-NAD-C21H27N7O13SP2-Purity:≥ 90%4090-29-3SASNADP 硫代辅酶IIThio-NADP-C21H27N7O16P3S•Na- Purity:≥ 90%19254-05-8SAAldNAD 3-吡啶⼄醛腺嘌呤⼆核苷酸3-Pyridinealdehyde adenine dinucleotide C21H27N6O14P21986-7-7SAAC1023-⼄酰基吡啶腺嘌呤⼆核苷酸磷酸钠(Ac-NADP) APADP-C22H28N6O17P3•Na -Purity:≥ 80%102029-67-4SANAAD 烟酸腺嘌呤⼆核苷酸Nicotinic Acid Adenine Dinucleotide- C21H26N6O15P2104809-30-5SADeNAD 脱氨基NADDeamino Nicotinamide Adenine Dinucleotide-C21H26N6O15P2104809-38-3SAGGNAFB γ-L-⾕氨酰基-4-硝基苯胺Gamma-L-glutamyl-4-nitroanilide,-C11H13N3O5-Purity:≥ 96%7300-59-6SACGGN L-γ-⾕氨酸-(3-甲酸-4硝基苯胺)铵盐L-Glutamic Acid Gamma- (3-Carboxy-4-Nitroanilide),Ammonium Salt-C12H12N3O7P•NH4-Purity:≥ 96%63699-78-5SAPEPCHA 磷酸烯醇丙酮酸单环⼰胺盐PEP-C3H4O6P•C6H13N-Purity :＞95%10526-80-4SAPEPK 磷酸烯醇式丙酮酸单钾盐PEP-C3H4O6P•K-Purity :＞95%4265-07-03.诊断与研究⽤的底物CODES PRODUCTS CAS #SCAKE05C α–酮戊⼆酸⼆钠盐⼆⽔合物α–Ketoglutaric acid, disodium salt dihydrate-C5H4O5Na2.2H2O-Mw:226.10 -White powder-Purity:>98%305-72-6α–酮戊⼆游离酸328-50-7SCAKE115C α–酮戊⼆游离酸α–Ketoglutaric free acid-C5H4O5-Mw:146.10 -White powder-Purity:>99%328-50-7SCBTC06S-丁酰硫胆碱碘S-Butyrylthiocholine Iodide-C9H20NOSI-Mw:317.23 -White powder-Purity:>97%1866-16-6SCCNP005Gal-G2-α-CNP-C28H51O18Cl-Mw:659.98 -White powder-Purity:>90 %157381-11-8SCCRP59C 磷酸肌酸⼆钠盐四⽔合物Phosphocreatine disodium salt tetrahydrate-C4H8N3O5PNa2.4H2O-Mw:327.15 -White powder-Purity:>97 %19333-65-4SCGGC106C ⽢氨酰⽢氨酸Glycylglycine-C4H8N2O3-Mw:132.12-White powder-Purity:>98 %556-50-3SCGLT100L-⾕氨酸L-Glutamic acid-C5H9N2O4- Mw:147.13-White powder-purity:＞99%617-65-2SCGPS15C 葡萄糖-6-磷酸⼆钠盐Glucose-6-phosphate disodium salt-C6H11O9PNa2-Mw:304.20-White powder-Purity:>95 %3671-99-6SCLAC171C DL-乳酸锂盐DL-Lactic acid Lithium salt-C3H5O3Li-Mw:96.01-White powder-Purity:>95%16891-53-5SCLAL29C L-丙氨酸游离酸L-Alanine free acid-C3H7NO2-Mw:89.09-White powder-Purity:>99%56-41-7SCLAP41C L-天门冬氨酸L-Aspartic acid-C4H7NO4-Mw:133.10-White powder-Purity:>99 %56-84-8SCLAP42C L-天门冬氨酸,钠盐⼀⽔合物L-Aspartic acid, sodium salt monohydrate-C4H6NO4Na.H2O-Mw:173.10-White powder-Purity:>98 %323194-76-9SCLAP43C L-天门冬氨酸,镁⼆⽔合物L-Aspartic acid, magnesium salt dihydrate-C8H12N2O8Mg.2H2O-MW:324.50-White powder-Purity:>98 %2068-80-6SCLGC244C L-γ-⾕氨酰-3-羧基-4-硝基苯胺Glupa C-L-γ-Glutamyl-3-carboxy-4-nitranilide-C12H12N3O7NH4-Mw:328.30-Yellow powder-Purity:>99 %63699-78-5SCNAY138C 萘磷酸单钠盐Naphtyl phosphate, monosodium salt-C10H8NaO4P.H2O-Mw:264.15-White powder-Purity:>98%81012-89-7SCPG701C 亚⼄基降-4-硝基苯基-β-D-麦芽庚糖苷pNP-G7-Ethylidene-4-nitrophenyl-D-maltoheptaoside-C50H77NO38-Mw:1300.10-Yellowish powder-Purity:>90%96597-16-9对硝基苯基磷酸酯，⼆钠盐六⽔合物4264-83-9SCPNP264C 对硝基苯基磷酸酯，⼆钠盐六⽔合物PNPP-p-Nitrophenylphosphate, disodium salt hexahydrate-C6H4NO6PNa2.6H2O-Mw :371.10-White to yellow powder-Purity:>98%4264-83-9SCPNS265C p-硝基苯基磷酸酯，⼆tris盐PNPP diTris-p-Nitrophenylphosphate, ditris salt-C14H28N3O12P-Mw:461.40-White powder68189-42-4SCPYN100丙酮酸钠Sodium pyruvate-C3H3NaO3-Mw:110-White powder-Purity:>99%113-24-64.缓冲液Buffers for diagnostic & researchPRODUCTS CAS # N-(2-⼄酰胺基)-2-氨基⼄磺酸ACES-N-(2-Acetamido)-2-aminoethanesulfonic acid7365-82-4N-(2-⼄酰胺基)亚氨基⼆⼄酸ADA-(N-(2-Acetamido)iminodiacetic acid)26239-55-4 2-氨基-2-甲基-1-丙醇AMT -2-amino-2-methyl-1-propanol124-68-5 N,N-双(2-羟⼄基)-2-氨基⼄磺酸BES-N,N-Bis-(2-Hydroxyethyl)-2-Aminoethanesulfonic acid10191-18-1 N,N-双-(2-羟基⼄基)⽢氨酸Bicine-N,N-Bis-(2-Hydroxyethyl)glycine150-25-4 N-环⼰基-3-氨基丙磺酸CAPS-N-Cyclohexyl-3-aminopropanesulfonicacid1135-40-6N-环⼰基-2-羟基-3-氨基丙磺酸CAPSO -N-Cyclohexyl-2-hydroxy-3-aminopropanesulfonic acid73463-39-5。

国家药监局关于批准注册121个医疗器械产品的公告(2021年3月)文章属性•【制定机关】国家药品监督管理局•【公布日期】2021.04.15•【文号】国家药品监督管理局公告2021年第55号•【施行日期】2021.04.15•【效力等级】部门规范性文件•【时效性】现行有效•【主题分类】药政管理正文国家药品监督管理局公告2021年第55号国家药监局关于批准注册121个医疗器械产品的公告(2021年3月)2021年3月，国家药品监督管理局共批准注册医疗器械产品121个。

其中，境内第三类医疗器械产品77个，进口第三类医疗器械产品18个，进口第二类医疗器械产品24个，港澳台医疗器械产品2个（具体产品见附件）。

特此公告。

附件：2021年3月批准注册医疗器械产品目录国家药监局2021年4月15日附件2021年3月批准注册医疗器械产品目录序号产品名称注册人名称注册证编号境内第三类医疗器械1导引系统先健科技（深圳）有限公司国械注准202130301522一次性使用防针刺精密过滤输液器带针上海宝舜医疗器械有限公司国械注准202131401533导引导管南京沃福曼医疗科技有限公司国械注准20213030154 4血液透析滤过器威海威高血液净化制品有限公司国械注准20213100155 5一次性使用压力延长管深圳市保安医疗用品有限公司国械注准20213030156 6硬脑膜修补片北京博辉瑞进生物科技有限公司国械注准20213130157 7一次性使用单向阀多通连接江苏省华星医疗器械实业有限公国械注准器司202131401588椎间融合器深圳市沃尔德外科医疗器械技术有限公司国械注准202131301599一次性使用精密过滤输液器带针淄博侨森医疗用品股份有限公司国械注准2021314016010椎间融合器武汉德骼拜尔外科植入物有限公司国械注准2021313016111不可吸收带线锚钉北京市富乐科技开发有限公司国械注准20213130162 12一次性使用静脉留置针苏州鑫康道医疗科技有限公司国械注准20213140163 13冠脉球囊扩张导管苏州莱诺医疗器械有限公司国械注准20213030164 14一次性使用输液器带针天津市远东医材有限公司国械注准20213140165 15外周球囊扩张导管北京永益润成科技有限公司国械注准20213030166 16一次性使用体外循环管道常州市康心医疗器械有限公司国械注准20213100167 17钛合金手足锁定接骨板系统创美得医疗器械（天津）有限公司国械注准20213130168 18一次性使用血管内成像导管苏州阿格斯医疗技术有限公司国械注准20213060169 19一次性内镜用注射针诸暨市鹏天医疗器械有限公司国械注准20213140170 20分段控弯导引系统先健科技（深圳）有限公司国械注准20213030171 21一次性使用血液透析管路健帆生物科技集团股份有限公司国械注准2021310017222可折叠人工晶状体天津世纪康泰生物医学工程有限公司国械注准2021316017323乙型肝炎病毒核酸测定试剂上海仁度生物科技有限公司国械注准盒（RNA捕获探针法）2021340017424一次性使用电子输尿管肾盂内窥镜导管北京北方腾达科技发展有限公司国械注准2021306017525新型冠状病毒2019-nCoV核酸检测试剂盒（荧光PCR法）杭州迪安生物技术有限公司国械注准2021340017626儿童手部X射线影像骨龄辅助评估软件杭州依图医疗技术有限公司国械注准2021321017727病人监护仪通用电气医疗系统（中国）有限公司国械注准2021307017828三维腹腔内窥镜山东威高手术机器人有限公司国械注准2021306017929单光子发射计算机断层成像系统滨松光子医疗科技（廊坊）有限公司国械注准2021306018030一次性使用热活检钳诸暨市鹏天医疗器械有限公司国械注准2021301018131一次性使用高频十二指肠乳头切开刀杭州莱恩瑟特医疗技术有限公司国械注准2021301018232生物安全柜苏州安泰空气技术有限公司国械注准2021322018333一次性使用Y型连接阀套装厦门鑫康顺医疗科技有限公司国械注准2021303018434预充式导管冲洗器山东赛克赛斯生物科技有限公司国械注准20213140185 35锚钉系统大博医疗科技股份有限公司国械注准20213130186 36泡沫敷料广州润虹医药科技股份有限公司国械注准2021314018737一次性使用精密过滤避光输液器山东新华安得医疗用品有限公司国械注准2021314018838软性亲水接触镜江苏天眼医药科技股份有限公司国械注准2021316018939一次性使用无菌注射器带针江苏采纳医疗科技有限公司国械注准2021314019040注射用交联透明质酸钠凝胶杭州科腾生物制品有限公司国械注准20213130191 41血液透析浓缩液四川威力生医疗科技有限公司国械注准2021310019242一次性使用防针刺静脉输液针山东威高集团医用高分子制品股份有限公司国械注准2021314019343一次性使用避光输液器河南曙光汇知康生物科技股份有限公司国械注准2021314019444一次性使用精密过滤输液器带针南阳市久康医疗器械有限公司国械注准2021314019545一次性使用无菌自毁式注射器聚民生物科技有限公司国械注准2021314019646夹子装置诸暨市鹏天医疗器械有限公司国械注准2021302019747一次性使用无菌注射针江苏采纳医疗科技有限公司国械注准20213140198 48颅内支撑导管北京久事神康医疗科技有限公司国械注准20213030199 49软性亲水接触镜江苏天眼医药科技股份有限公司国械注准2021316020050一次性使用无菌注射器带针成都市新津事丰医疗器械有限公司国械注准2021314020151一次性使用静脉留置针佳康医用器材（青岛）有限公司国械注准20213140202 52颅内球囊扩张导管依奈德医疗技术（上海）有限公司国械注准2021303020353一次性使用压力延长管山东威高集团医用高分子制品股份有限公司国械注准2021314020454颅内球囊扩张导管浙江归创医疗器械有限公司国械注准2021303020555远端通路导引导管珠海通桥医疗科技有限公司国械注准20213030206 56导管鞘沛嘉医疗科技（苏州）有限公司国械注准20213030207 57一次性使用注射笔用针头甘甘医疗科技江苏有限公司国械注准2021314020858麻醉系统通用电气医疗系统（中国）有限公司国械注准2021308020959肺炎CT影像辅助分诊与评估软件北京推想科技有限公司国械注准2021321021060肺炎CT影像辅助分诊与评估软件杭州深睿博联科技有限公司国械注准2021321021161医用血管造影X射线机东软医疗系统股份有限公司国械注准20213060212 62复合陡脉冲治疗设备上海睿刀医疗科技有限公司国械注准2021309021363放射治疗轮廓勾画软件海创时代（深圳）医疗科技有限公司国械注准2021321021464口腔种植手术导航定位设备北京柏惠维康科技有限公司国械注准20213010215 65超导型磁共振成像系统康达洲际医疗器械有限公司国械注准2021306021666人附睾蛋白4测定试剂盒（化学发光法）深圳市亚辉龙生物科技股份有限公司国械注准2021340021767胃泌素释放肽前体测定试剂盒（化学发光法）深圳市亚辉龙生物科技股份有限公司国械注准2021340021868前列腺酸性磷酸酶测定试剂盒（化学发光免疫分析法）苏州长光华医生物医学工程有限公司国械注准2021340021969神经元特异性烯醇化酶测定试剂盒（化学发光免疫分析法）苏州长光华医生物医学工程有限公司国械注准2021340022070乙型肝炎病毒前S1抗原检迈克生物股份有限公司国械注准测试剂盒（直接化学发光法）2021340022171人JAK2-V617F基因突变检测试剂盒（荧光PCR法）迈杰转化医学研究（苏州）有限公司国械注准2021340022272一次性使用血液透析器广州市恩德氏医疗制品实业有限公司国械注准2021310022373流出道单瓣补片北京佰仁医疗科技股份有限公司国械注准20213130224 74一次性使用静脉留置针威海洁瑞医用制品有限公司国械注准20213140225 75软聚硅酮泡沫敷料江苏诺瓦立医疗用品有限公司国械注准2021314022676幽门螺杆菌23S rRNA基因突变检测试剂盒（PCR-荧光探针法）上海芯超生物科技有限公司国械注准2021340022777新型冠状病毒2019-nCoV核酸检测试剂盒（荧光PCR法）重庆中元汇吉生物技术有限公司国械注准20213400228进口第三类医疗器械78血液透析用中心静脉导管及附件Covidien llc国械注进2021310005779钛夹AESCULAP AG国械注进20213020058 80注射用交联透明质酸钠凝胶Q-Med AB国械注进2021313005981颅内取栓支架Micro Therapeutics,Inc.dba ev3Neurovascular国械注进2021303006082游离前列腺特异性抗原校准品Siemens Healthcare DiagnosticsProducts Limited国械注进2021340007383丙型肝炎病毒（HCV）核酸（RNA）检测试剂盒（实时荧光PCR法）Cepheid AB国械注进2021340007484抗CD20（L26）鼠单克隆抗体试剂（免疫组织化学Ventana Medical Systems, Inc.国械注进20213400075法）85牙科种植体Zimmer Dental, Inc.国械注进20213170076 86空心纤维血液透析器Vital Healthcare Sdn. Bhd.国械注进20213100077 87一次性负压装置及护创敷料Smith & Nephew Medical Ltd国械注进20213140090 88双极器械ERBE Elektromedizin GmbH国械注进2021301009189一次性使用高频圈套器オリンパスメディカルシステムズ株式会社国械注进2021301009290麻醉系统Dr?gerwerk AG & Co. KGaA国械注进20213080093 91X射线计算机体层摄影设备Siemens Healthcare GmbH国械注进20213060094 92关节内窥镜（?）国械注进20213060095 93电子下消化道内窥镜富士フイルム株式会社国械注进20213060096 94植入式给药装置专用针Fresenius Kabi AG国械注进20213140097 95微导管Vascular Solutions LLC国械注进20213030098进口第二类医疗器械96胰岛素样生长因子-1检测试剂盒（电化学发光法）Roche Diagnostics GmbH国械注进2021240006197免疫球蛋白E校准品DiaSys Diagnostic Systems GmbH国械注进2021240006298纤维蛋白原质控品（低值）Instrumentation LaboratoryCompany国械注进2021240006399一次性使用直线型切割吻合器及渐进式钉匣Covidien llc国械注进20212020064100血糖仪OSANG Healthcare Co.,Ltd.国械注进20212220065 101血糖仪OSANG Healthcare Co.,Ltd.国械注进20212220066102内窥镜图像处理及照明装置オリンパスメディカルシステムズ株式会社国械注进20212060067103内镜清洗消毒器STEELCO SPA国械注进20212110068 104电动产床タカラメディカル株式会社国械注进20212180069 105角膜内皮显微镜株式会社コーナン?メディカル国械注进20212160070106肺功能测试系统GANSHORN Medizin ElectronicGmbH国械注进20212070071107牙科低压电动马达株式会社ナカニシ国械注进20212170072108抗β2糖蛋白1结构域1IgG抗体检测试剂盒（化学发光免疫分析法）INOVA Diagnostics, Inc.国械注进20212400078109胱抑素C校准液Siemens Healthcare DiagnosticsInc.国械注进20212400079110降钙素原校准品Ortho-Clinical Diagnostics国械注进20212400080111胰岛素样生长因子-I测定试剂盒（化学发光法）Siemens Healthcare DiagnosticsProducts Limited国械注进20212400081112降钙素原质控品Ortho-Clinical Diagnostics国械注进20212400082113喷砂洁牙机SATELEC A Company ofACTEON Group国械注进20212170083114种植体稳固度检测仪Osstell AB国械注进20212170084 115多导睡眠记录系统SOMNOmedics GmbH国械注进20212070085 116一次性使用超声内窥镜水囊HOYA株式会社豪雅株式会社国械注进20212060086 117多导睡眠记录系统SOMNOmedics GmbH国械注进20212070087 118全自动微生物质谱检测系统ASTA Corporation国械注进20212220088119齿科铸造合金Eisenbacher Dentalwaren EDGmbH国械注进20212170089港澳台医疗器械120软性亲水接触镜望隼科技股份有限公司国械注许20213160003 121软性亲水接触镜星歐光學股份有限公司国械注许20213160004。

莪术油注射液1材料与仪器细胞株：人卵巢癌SKOV3细胞购自中国医学科学院肿瘤研究所,由广西肿瘤防治研究所临床中心实验室传代保存。

细胞用含有10%灭活小牛血清、100U/ml青霉素、100μg/ml链霉素的RPMI-1640培养液于37℃、5%CO2条件下培养。

MR-300酶标仪为美国产,倒置显微镜为日本产。

MTT(噻唑蓝)购自Sigma公司,RPMI1640和小牛血清为Gibco公司产品，其余均为国产分析纯试剂。

莪术油注射液购自黑龙江瑞格制药有限公司（生产批号：051101,国药准字：H20023314）。

2.1噻唑蓝(MTT)法确定莪术油注射液对卵巢癌SKOV3细胞的存活抑制作用取对数生长期的卵巢癌SKOV3细胞,浓度为5×103个/ml，加入到96孔板，每孔加含细胞的培养液180μl,置37℃,5%CO2培养箱孵育24h后,以依次加入终浓度为15.625，31.25，62.5，125，250μg/ml莪术油注射液,同时以1640培养液作为空白对照组,每孔的终体积均为200μl，分别培养12，24，36，48h后加入20μlMTT(2g·L-1),37℃,5%CO2培养箱孵育4h后,弃上清液,每孔加入DMSO200μl,于492nm波长处测定吸光度OD值，每个浓度平行测定3孔。

按下列公式求出生长抑制率(IR)，通过由IR对浓度作图,求出半数抑制浓度IC50。

实验重复3次取平均值。

生长抑制率IR（%）=（1-实验组平均A值/空白对照平均A值）×100%2.2细胞形态学观察倒置显微镜观察：细胞爬片后,分别加入31.25，62.5，125μg/ml浓度的莪术油注射液作用48h后，倒置显微镜观察，摄片。

2.3统计学处理所有数据用SPSS11.0软件实行单因素方差分析分析，计量资料结果以±s表示，当P＜0.05认为差异有显著性意义。

3结果3.1MTT法检测结果MTT法检测不同浓度、不同时间莪术油注射液对SKOV3细胞抑制效果，见表1。

Cardinal Health™ Nutritional Delivery2023 Enteral Nutrition Coding GuideReference: 1. Alpha-Numeric HCPCS. Centers for Medicare & Medicaid Services. https:///Medicare/Coding/HCPCSReleaseCodeSets/Alpha-Numeric-HCPCS. Last modified November 28, 2022. Accessed November 28, 2022.* CMS 2023 Alpha-Numeric HCPCS File; https:///Medicare/Coding/HCPCSReleaseCodeSets/Alpha-Numeric-HCPCS † CMS Coverage Limits in LCD L33783Note for Medicare patients: Enteral feeding supply kits (B4034-B4036) have a one-unit daily allowance; therefore, refill requirements are not applicable to these HCPCS codes. These codes must also correspond with the method of administration indicated in question 5 of the Medicare DME Information Form (CMS-10126) at https:///Medicare/CMS-Forms/CMS-Forms/downloads/cms10126.pdf.The codes contained in this guide are for informational purposes only and are not intended to serve as reimbursement advice. The information is taken from materials published by the Centers for Medicare and Medicaid Services and the American Medical Association and may be helpful to providers in staying up to date on reimbursement codes. This information is current at the time of publication of this document and subject to change. This information cannot guarantee coverage or reimbursement. Cardinal Health makes no other representations as to selecting codes for products or services or compliance with any other billing protocols or requirements. Providers should consult with each patient’s health plan directly for appropriate coverage, medical necessity, coding and billing requirements for products and services provided.© 2023 Cardinal Health. All Rights Reserved. CARDINAL HEALTH, the Cardinal Health LOGO, KANGAROO, ARGYLE, MONOJECT and DOBBHOFF are trademarks of Cardinal Health and may be registered in the US and/or in other countries. All other marks are the property of their respective owners. Patent /patents. Lit. No. 2GM20-1308734 (01/2023)Supplies and kits (continued)B4034Enteral feeding supply kit; syringe fed, per day,includes but not limited to feeding/day, includes but not limited to feeding/flushing syringe, administration set tubing, dressings, tape KANGAROO™ I.V. Pole Pouch and Kit MONOJECT™ Enteral Syringe with Tip Cap (all sizes) MONOJECT™ Medicine Syringe Straw (all sizes) KANGAROO™ Milk Straw KANGAROO™ Feeding Tube Extension Set with ENFit® Connection KANGAROO™ Bifurcated Extension Set with ENFit® Connection B4035Enteral feeding supply kit; pump fed, per day,includes but not limited to feeding/flushing syringe, administration set tubing, dressings, tape tubing, dressings, tapeKANGAROO™ ePump 500 mL or 1,000 mL SetKANGAROO™ ePump 1,000 mL Set with 1,000 mL Flush Bag KANGAROO™ ePump ENPlus Spike Set KANGAROO™ ePump ENPlus Spike Set with 1,000 mL Flush Bag KANGAROO™ ePump Burette 100 mL SetKANGAROO™ Joey Pump 500 mL or 1,000 mL Set KANGAROO™ Joey ENPlus Spike SetKANGAROO™ Joey 1,000 mL Set with 1,000 mL Flush Bag KANGAROO™ Joey ENPlus Spike Set with 1,000 mL Flush Bag KANGAROO™ Connect ENPlus Spike Set Non-Sterile KANGAROO™ Connect Feeding Set 500 mL or 1,000 mL KANGAROO™ Irrigation Piston Syringe 60 mLKANGAROO™ Irrigation Syringe with 500 mL Container 60 mL Piston SyringeKANGAROO™ Irrigation Syringe with 500 mL Container 60 mL Piston Syringe, Basin KANGAROO™ Y-Port/PEG Adapter (all colors/sizes)KANGAROO™ Y-Site Extension 6 in. (15.2 cm)B4036Enteral feeding supply kit; gravity fed, per day,includes but not limited to per day, includes but not limited to feeding/flushing syringe, administration set tubing, dressings, tape KANGAROO™ Gravity Feeding Bag Large Bore 1,000 mL KANGAROO™ Gravity Feeding Bag 1,000 mLB9998Not for enteral suppliesKANGAROO™ Bolus Feeding Kit Bulb Syringe KANGAROO™ CO Detector with Bellows †KANGAROO™ ePump Backpack KANGAROO™ ePump Pole ClampKANGAROO™ ePump Power Adapter Plug KANGAROO™ Connect Backpack KANGAROO™ Joey Power Cord KANGAROO™ Joey Pole ClampKANGAROO™ Joey Mini and Super Mini Backpacks (all colors)KANGAROO™ Skin Level Stoma Measuring Device Tube Access KANGAROO™ Skin Level Tube Access Bolus Feeding SetKANGAROO™ Skin Level Tube Access Continuous Right Angle Feeding Set KANGAROO™ Connect Enteral Feeding Pole Clamp********************************。

《国际药学研究杂志》原名《国外医学药学分册》，是军事医学科学院主管、军事医学科学院毒物药物研究所和中国药学会主办的大型综合性药学刊物，为月刊，国内外公开发行。

设置有专家论坛、专题报道、综述、论著、医药信息等栏目。

本刊以从事药学研究的科技人员、临床医师和药师、制药工程技术人员、医药院校师生为读者对象，根据国内药学科研、教学、临床和生产的需要，追踪报道国际药学领域的新进展、新动向、新技术和新成果，包括药物化学、药剂学、药物代谢、药物分析、药理和毒理学、生化药学和临床药学等基础研究和应用研究方面的内容。

是中国科技论文统计源期刊（中国科技核心期刊）、北大图书馆中文核心期刊，中国生物医学核心期刊，被美国《化学文摘》、美国《剑桥科学文摘》、荷兰《医学文摘》、世界卫生组织西太平洋地区医学索引、英国《农业与生物科学研究中心数据库》、中国核心期刊（遴选）数据库、中文科技期刊数据库、中国学术期刊综合评价数据库、中国生物医学期刊引文数据库、中文生物医学期刊文献数据库、中国药学文献数据库和中国生物学文献数据库等多个国内外权威检索系统收录。

2011、2014年连续两届被评为“中国精品科技期刊”。

多篇论文入选“F5000中国精品科技期刊顶尖学术论文”及中国药学会优秀论文。

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专利名称：中药诱导骨髓间质细胞分化为神经元样细胞的方法专利类型：发明专利
发明人：李海标,撒亚莲
申请号：CN02134983.5
申请日：20021018
公开号：CN1410530A
公开日：
20030416
专利内容由知识产权出版社提供
摘要：本发明涉及一种骨髓间质细胞的定向分化技术。

本技术包括bFGF预诱导和定向诱导MSC向神经元样细胞分化两个步骤：(1)bFGF预诱导：用含有胚牛血清和bFGF的低糖DMEM培养；(2)定向诱导MSC向神经元样细胞分化：用含有中药成分的无血清低糖DMEM中诱导。

本发明具有高效、安全性好、来源丰富经济等优点。

申请人：中山大学
地址：510275 广东省广州市新港西路135号
国籍：CN
更多信息请下载全文后查看。

专利名称：一种治疗动脉粥样硬化的药物组合物及其制备方法和用途
专利类型：发明专利
发明人：周碧蓉
申请号：CN201810746549.3
申请日：20180709
公开号：CN110693881A
公开日：
20200117
专利内容由知识产权出版社提供
摘要：本发明开了一种治疗动脉粥样硬化的药物组合物，包括重量比为4:1的阿托伐他汀和全反式维甲酸。

本发明将传统型阿托伐他汀以及传统治疗理念升级为降脂、调脂、抗炎、稳定斑块及抗新生血管为一体的阿托伐他汀全反式维甲酸自组装共给药纳米递送系统。

新的药物剂型可以实现靶向精准治疗AS，新的治疗理念可以实现有效缩小稳定AS斑块，从根本上减少心血管事件的发生。

申请人：安徽医科大学
地址：230022 安徽省合肥市梅山路81号
国籍：CN
代理机构：北京金蓄专利代理有限公司
代理人：陈雷
更多信息请下载全文后查看。