安慰剂 互相对照 自身对照 标准对照 历史对照 均匀性 均匀的 前提条件 随意 重复 预试验 血沉 化学疗法 缓解率 对象选择 处理安排 数据搜集 效度 可重复 animal experiment community intervention trial intervene eligible subjects factor treatment factor non-treatment factors level objective accurate precise specific sensitive Chapter 13 Design of medical research Chapter 13 Design of Medical Research (I) design research design reliable random error efficiency laboratory experiment clinical trial medical survey control balance randomization replication treatment subject effect empty control 设计 研究设计 可靠 随机误差 效率 实验室实验 临床试验 医学调查 对照、对照组 均衡 随机化 重复 处理 对象 效应 空白对照 9.1 Statistical Description for Measurement Data Vocabulary for Chapter 9-1 Frequency Distribution Frequency table Minimum maximum range Inter- quartile range Lower Quartile upper Quartile interval Cumulative frequency Count 频率分布 频率表 最小值 最大值 范围、极差 四分位数间距 下四分位数 上四分位数 区间 累积频率 记数 动物实验 社区干预试验 干预 合格对象 因素 处理因素 非处理因素 水平 客观性 准确 精确 特异的 敏感的 The aim of research design: To get a reliable result in the lowest cost of manpower, time and money; To estimate the random error within the observed data; To promote the efficiency of the research Medical Statistics (full English class) Ji-Qian Fang School of Public Health Sun Yat-Sen University Chapter 9 Statistical Analysis For Measurement Data Table 9 -2 Height of 130 female children Height 124 128 132 136 140 144 148 15215616 0-164 Total Count 正正 正正正正 正正正正正正正 正正正正正 正正正 正 Freq. 2 3 11 22 39 27 16 5 3 2 130 (1) Steps a. Minimum, maximum and range. Range=162.6-125.9=36.7 b. Decide the interval of group. c. Build up the table. Count the observations, Frequency Cumulated frequency 1. Frequency Distribution Example 9-1 There are 130 observations on height of 14 years old female children (Table 9-1). Look at the raw data? vague and confuse! How to sort the data? ---- Frequency table ! placebo mutual control self control standard control historical control homogeneity homogeneous prerequisite casual reproduce pilot study blood sedimentation chemotherapy remission rate subject selection treatment assignment data collection validity reproducible There are two kindFra Baidu bibliotek of research: Laboratory experiment and Clinical trial Medical survey 13.1 Principles of research design 1. 2. 3. 4. Control Balance Randomization Replication (2) The use of frequency table Show the profile of data distribution. Symmetric? Skew ? Central position? Variability? Outliers? Frequency table is a good way to summarize the data ---- 130 figures are reduced to 22 figures and are much easier to present.