- 1、下载文档前请自行甄别文档内容的完整性,平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益,请联系客服反馈,我们会尽快为您处理(人工客服工作时间:9:00-18:30)。
Q. AZIZ, et al., Gut microbiota and gastrointestinal health: current concepts and future directions. Neurogastroenterol Motil (2013) 25, 4–15.
菌群影响神经功能
一篇值得关注的综述
Nature reviews. Microbiology 最新的影响因子为22.490 (2013)
Байду номын сангаас
人菌共生
Kristina Harris,et al., Is the GutMicrobiota a New Factor Contributing to Obesity and ItsMetabolic Disorders? Journal of Obesity, Volume 2012, p 1-14.
肠-脑轴的概念
Augusto J. Montiel-Castro, et al., The microbiota–gut–rainaxis: neurobehavioral correlates, healthand sociality. Front in Integ Neuro. Oct 2013 | Vol7 | Article 70 | 1-16.
菌群紊乱致焦虑和抑郁
Jane A. Foster and Karen-Anne McVey Neufeld, Gut–brain axis: how the microbiome influences anxiety and depression. Trends in Neurosciences, May 2013, Vol. 36, No. 5, P 305312
Eamonn M.M. Quigley. Do patients with functional gastrointestinal disorders have an altered gut flora? Ther Adv Gastroenterol (2009) 2(Suppl 1) S23–S30.
脑-肠轴/肠-脑轴:迷走神经
Sue Grenham,et al., Brain–gut–microbe communication in health and disease. Frontiers in Physio. Gastroint Sci Dec 2011 Vol 2 p 1-15.
肠脑轴/脑肠轴
好细菌和坏细菌
菌群是健康的核心
Nathalie M. Delzenne, et al., Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat. Rev. Endocrinol. 7, 639–646 (2011).
影响肠道菌群的因素
肠-脑轴/脑-肠轴
• Germ Free (GF) Mice Display Increased Motor Activity and Reduced Anxiety-Like Behavior.
• results suggest that the microbial colonization process initiates signaling mechanisms that affect neuronal circuits involved in motor control and anxiety behavior.
肠道菌群与代谢疾病
目录
• 肠道菌群与健康和疾病概述 • 肠-脑轴 • 肠-肝轴 • 肠道菌群与代谢性疾病:肥胖、糖尿病 • 肠道菌群与肠病 • 肠道菌群与免疫 • 肠道菌群与其它疾病 • 革命带来的挑战和机遇
悄悄发生的革命
INNA SEKIROV, et al., Gut Microbiota in Health and Disease. Physiol Rev 90: 859–904, 2010;
精神活动影响肠道菌群
exposure to psychological stress results in a significant reduction in the production of mucin and a decreased presence of acidic mucopolysaccharides on the mucosal surface.
Jason A. Hawrelak & Stephen P. Myers, The Causes of Intestinal Dysbiosis: A Review. Altern Med Rev 2004;9(2):180-197.
应激/压力引起胃肠疾病
P.C. KONTUREK, et al., STRESS AND THE GUT: PATHOPHYSIOLOGY, CLINICAL CONSEQUENCES, DIAGNOSTIC APPROACH AND TREATMENT OPTIONS. J PHYSIO & PHARM 2011, 62, 6, 591-599.
人肠道菌群种类和数量
EAMONN M. M. QUIGLEY and RODRIGO QUERA, Small Intestinal Bacterial Overgrowth: Roles of Antibiotics, Prebiotics, and Probiotics. GASTROENTEROLOGY 2006;130:S78–S90
肠道菌群对人生理的影响
肠道菌群-代谢产物-功能
Jeremy K. Nicholson et al., Host-Gut Microbiota Metabolic. Science 336, 1262-1267, 2012.
影响肠道菌群的因素
Nathalie M. Delzenne & Patrice D. Cani, Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition. Annu. Rev. Nutr. 2011. 31:15–31.